Product Description

Product Name: Homoharringtonine

Othere Name: Omacetaxine mepesuccinate [USAN]; Ceflatonin; Myelostat; 4-methyl-cephalotaxin2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate; Cephalotaxine,4-methyl(2r)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioa; Cephalotaxine 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate;

NSC 141633; BRN 5687925; CGX-635; Omapro; UNII-6FG8041S5B; 1-((1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H- cyclopenta(a)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-yl) 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate

 CAS No.:  26833-87-4      

Chemical Formula: C29H39NO9

Formula Weight: 545.62g/mol 

Assay: 98%

Appearance: Off-white powder

Identification method: Mass, NMR

Applicaton: Omacetaxine/ Homoharringtoninefor the determination and identification, pharmacological experiments.

Pharmacological effect: Omacetaxine/ Homoharringtonine cycle non-specific antineoplastic agents. Depolymerize ribosome; inhibit protein synthesis; reduce mitotic index of he tumor; decrease nucleic acid content of tumor tissue; mainly used in clinical acute promyelocytic leukemia; acute monocytic leukemia, acute myeloid leukemia and malignant lyMelting Pointhoma; can also be used for chronic myeloid leukemia, polycythemia vera psychosis.

TEST ITEM	SPECIFICATION	RESULTS
Appearance	Kind of white or  light yellow crystalline powder	Kind of white crystalline Powder
Solubility	Soluble in ethanol, methanol, Chloroform, Slightly soluble in water and ethyl ether	Conform
Assay (HPLC)	95% -103%	99.45%
Melting Point	143°C ­-147°C	144°C-146°C
Loss on Drying	≤2.0%	0.65%
Heavy Metals	≤20 ppm	10ppm
Total Impurities	≤2.0%	0.53%
Known single impurities	≤0.5%	0.28%
Unknown single impurities	≤0.1%	0.08%
Residual Solvent	Meets the requirements of ICH	Conform
Acetone	≤5000ppm	300ppm
Methanol	≤3000ppm	58ppm
Chloroform	≤5000ppm	400ppm
Dichloromethane	≤3000ppm	Absence
Microbial Limits
Total aerobic microbial count	≤1000 cfu/g	60 cfu/g
Yeast & Mold	Absence	Absence
Salmonella species	Absence	Absence
Escherichia Coli	Absence	Absence
CONCLUSION	Conform to the specifications

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